Alergia e intolerancia a antiinflamatorios no esteroides: desensibilización exitosa en tres casos y revisión de la literatura

  • Ricardo Cardona Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
  • Ruth Helena Ramírez Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
  • Zulma Reina Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia
  • Mauricio Fernando Escobar Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
  • Edison Morales Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Palabras clave: hipersensibilidad a los medicamentos, aspirina, agentes antiinflamatorios no esteroides, desensibilización inmunológica, asma, anafilaxis, pólipos nasales, sinusitis

Resumen

Los antiinflamatorios no esteroides son la segunda causa de reacciones a medicamentos después de los beta-lactámicos. La prevalencia de las reacciones a antiinflamatorios no esteroideos en la población general es de 0,1% a 0,3% y la prevalencia de anafilaxia inducida por ellos es de 0,01%.
La intolerancia al ácido acetilsalicílico o a los antiinflamatorios no esteroides se presenta con síntomas como urticaria aguda, angioedema, crisis asmática, enfermedad respiratoria exacerbada por ácido acetilsalicílico y anafilaxia.
Presentamos una revisión actualizada basada en tres casos de pacientes con intolerancia al ácido acetilsalicílico o a los antiinflamatorios no esteroideos que, por sus enfermedades concomitantes, requerían tratamiento permanente conácido acetilsalicílico. Después de someterlos a un protocolo de desensibilización rápida ácido acetilsalicílico en una unidad de cuidados intensivos, estos pacientes pudieron continuar recibiendo ácido acetilsalicílico diariamente sin efectos adversos.

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Cómo citar
Cardona, R., Ramírez, R., Reina, Z., Escobar, M., & Morales, E. (1). Alergia e intolerancia a antiinflamatorios no esteroides: desensibilización exitosa en tres casos y revisión de la literatura. Biomédica, 29(2), 181-190. https://doi.org/10.7705/biomedica.v29i2.20
Sección
Presentación de caso