Lesiones hepáticas nodulares por mieloma IgA como causa de fiebre de origen desconocido
Palabras clave:
fiebre de origen desconocido, mieloma múltiple, hígado, inmunoglobulina A
Resumen
Se presenta el caso de un paciente de 45 años de edad, de sexo masculino, con antecedentes de mieloma múltiple IgA y trasplante autólogo de células progenitoras, que consultó un cuadro de seis semanas de fiebre asociada a sintomatología constitucional.Las pruebas hepáticas mostraron compromiso por infiltración celular. En la ecografía hepática se evidenciaron múltiples lesiones nodulares, identificadas como focos circunscritos de mieloma en la biopsia por laparoscopia.
Éste podría ser el primer caso informado de fiebre de origen desconocido secundaria a lesiones hepáticas nodulares por mieloma.
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Referencias bibliográficas
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2. Lin P. Plasma cell myeloma. Hematol Oncol Clin North Am. 2009;23:709-27.
3. Ochoa LF, Montoya LP. Mortalidad por cáncer en Colombia 2001. Revista CES Medicina. 2004;18:19-36.
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5. Nucci M, Anaissie E. Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents. Clin Infect Dis. 2009;49:1211-25.
6. Hayes DW, Bennet WA, Heck FJ. Extramedullary lesions multiple myeloma. Arch Pathol. 1952;53:262-72.
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10. Goel S, Ghesani M, Cohen S, Maslin P, Meka M, Chang A. Multiple myeloma presenting with [18F] fluorodeoxyglucose avid liver lesions diagnosed on positron emission tomography scan. J Clin Oncol. 2007;25:5319-20.
11. Thiruvengadam R, Penetrante RB, Goolsby HJ, Silk YN, Bernstein ZP. Multiple myeloma presenting as space occupying lesions of the liver. Cancer. 1990;65:2784-6.
12. Curtis JM, Pellegrini V, Tappin JA. Case report: multiple myeloma -a rare presentation. Clin Radiol. 1995;50:63-4.
13. Kelekis NL, Semelka RC, Warshauer DM, Sallah S. Nodular liver involvement in light chain multiple myeloma: appearance on US and MRI. Clin Imaging. 1997;21:207-9.
14. Fernandez-Florez A, Fortes J, Smucler A, Orduna M, Pol A. Involvement of the liver by multiple myeloma as nodular lesions: a case diagnosed by fine-needle aspiration and immunocytochemistry. Diagn Cytopathol. 2003;29:280-2.
15. Invernizzi R, Maffe GC, Travaglino E, Pagani E, Pieresca C. Nodular lesions of the liver in multiple myeloma. Haematologica. 2007;92:e81.
16. Pérez-Soler R, Esteban R, Allende E, Tornos-Salomo C, Julia A, et al. Liver involvement in multiple myeloma. Am J Hematol. 1985;20:25-9.
17. Talamo G, Cavallo F, Zangari M, Barlogie B, Lee CK, Pineda-Román M et al. Clinical and biological features of multiple myeloma involving the gastrointestinal system. Haematologica. 2006;91:964-7.
18. Oshima K, Kanda Y, Nannya Y, Kaneko M, Hamaki T, Suguro M, et al. Clinical and pathological findings in 52 consecutively autopsied cases with multiple myeloma. Am J Hematol. 2001;67:1-5.
19. Wu XN, Zhao XY, Jia JD. Nodular liver lesions involving multiple myeloma: A case report and literature review. World J Gastroenterol. 2009;15:1014-7.
20. Edwards GA, Zawadzki ZA. Extraosseous lesions in plasma cell myeloma. A report of six cases. Am J Med.1967;43:194-205.
21. Wajima T, Teague OE. IgA-multiple myeloma presenting as plasmocytoma of the liver. J Clin Gastroenterol. 1992;15:270-1.
22. Heckmann M, Uder M, Grgic A, Adrian N, Bautz W, Heinrich M. Extraosseous manifestation of multiple myeloma with unusual appearance in computed tomography-case report. Roentgenpraxis. 2008;56:249-53.
23. Mathieu D, Elouaer-Blanc L, Diviné M, René E, Vasile N. Hepatic plasmacytomas: Sonographic and CT findings. J Comput Assist Tomogr. 1986;10:144-5.
24. Nozza A, Castagna L, Rahal D, Magagnoli M, Santoro A. Massive liver involvement in a patient with multiple myeloma during thalidomide treatment. Haema. 2003;6:230-2.
2. Lin P. Plasma cell myeloma. Hematol Oncol Clin North Am. 2009;23:709-27.
3. Ochoa LF, Montoya LP. Mortalidad por cáncer en Colombia 2001. Revista CES Medicina. 2004;18:19-36.
4. Thomas FB, Clausen KP, Greenberger NJ. Liver disease in multiple myeloma. Arch Intern Med. 1973;132:195-202.
5. Nucci M, Anaissie E. Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents. Clin Infect Dis. 2009;49:1211-25.
6. Hayes DW, Bennet WA, Heck FJ. Extramedullary lesions multiple myeloma. Arch Pathol. 1952;53:262-72.
7. Churg J, Gordon AJ. Multiple myeloma: Lesions of the extraosseous hemopoietic systems. Am J Clin Pathol. 1950;20:934-45.
8. Pasmantier MW, Azar HA. Extraskeletal spread in multiple cell myeloma: A review of 57 autopsied cases. Cancer. 1969;23:167-74.
9. Innes J, Newall J. Myelomatosis. Lancet. 1961;1:239-45.
10. Goel S, Ghesani M, Cohen S, Maslin P, Meka M, Chang A. Multiple myeloma presenting with [18F] fluorodeoxyglucose avid liver lesions diagnosed on positron emission tomography scan. J Clin Oncol. 2007;25:5319-20.
11. Thiruvengadam R, Penetrante RB, Goolsby HJ, Silk YN, Bernstein ZP. Multiple myeloma presenting as space occupying lesions of the liver. Cancer. 1990;65:2784-6.
12. Curtis JM, Pellegrini V, Tappin JA. Case report: multiple myeloma -a rare presentation. Clin Radiol. 1995;50:63-4.
13. Kelekis NL, Semelka RC, Warshauer DM, Sallah S. Nodular liver involvement in light chain multiple myeloma: appearance on US and MRI. Clin Imaging. 1997;21:207-9.
14. Fernandez-Florez A, Fortes J, Smucler A, Orduna M, Pol A. Involvement of the liver by multiple myeloma as nodular lesions: a case diagnosed by fine-needle aspiration and immunocytochemistry. Diagn Cytopathol. 2003;29:280-2.
15. Invernizzi R, Maffe GC, Travaglino E, Pagani E, Pieresca C. Nodular lesions of the liver in multiple myeloma. Haematologica. 2007;92:e81.
16. Pérez-Soler R, Esteban R, Allende E, Tornos-Salomo C, Julia A, et al. Liver involvement in multiple myeloma. Am J Hematol. 1985;20:25-9.
17. Talamo G, Cavallo F, Zangari M, Barlogie B, Lee CK, Pineda-Román M et al. Clinical and biological features of multiple myeloma involving the gastrointestinal system. Haematologica. 2006;91:964-7.
18. Oshima K, Kanda Y, Nannya Y, Kaneko M, Hamaki T, Suguro M, et al. Clinical and pathological findings in 52 consecutively autopsied cases with multiple myeloma. Am J Hematol. 2001;67:1-5.
19. Wu XN, Zhao XY, Jia JD. Nodular liver lesions involving multiple myeloma: A case report and literature review. World J Gastroenterol. 2009;15:1014-7.
20. Edwards GA, Zawadzki ZA. Extraosseous lesions in plasma cell myeloma. A report of six cases. Am J Med.1967;43:194-205.
21. Wajima T, Teague OE. IgA-multiple myeloma presenting as plasmocytoma of the liver. J Clin Gastroenterol. 1992;15:270-1.
22. Heckmann M, Uder M, Grgic A, Adrian N, Bautz W, Heinrich M. Extraosseous manifestation of multiple myeloma with unusual appearance in computed tomography-case report. Roentgenpraxis. 2008;56:249-53.
23. Mathieu D, Elouaer-Blanc L, Diviné M, René E, Vasile N. Hepatic plasmacytomas: Sonographic and CT findings. J Comput Assist Tomogr. 1986;10:144-5.
24. Nozza A, Castagna L, Rahal D, Magagnoli M, Santoro A. Massive liver involvement in a patient with multiple myeloma during thalidomide treatment. Haema. 2003;6:230-2.
Cómo citar
1.
González GR, Navarro AM, Zambrano Ángela R, Arrunátegui AM. Lesiones hepáticas nodulares por mieloma IgA como causa de fiebre de origen desconocido. biomedica [Internet]. 1 de diciembre de 2010 [citado 25 de abril de 2024];30(4):478-81. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/285
Publicado
2010-12-01
Número
Sección
Presentación de caso
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