DOI: https://doi.org/10.7705/biomedica.v38i4.4262

Efectos del ejercicio físico sobre la cognición en mujeres mayores tratadas con lovastatina

Edgardo Molina-Sotomayor, Rocío Arreguín-Moreno, Fernando Rodríguez-Rodríguez, Francisco Pradas, Juan Antonio León, José Antonio González-Jurado

Resumen


Introducción. El deterioro cognitivo tiene una gran incidencia en el adulto mayor.
Objetivo. El principal objetivo de este estudio fue analizar los efectos sobre la cognición y la concentración de lípidos de un programa de caminatas en mujeres mayores de 60 años tratadas con lovastatina.
Materiales y métodos. Las participantes se distribuyeron en dos grupos: uno con ejercicio (EG, n=45) sometido a entrenamiento aeróbico y otro inactivo o sedentario (SG, n=22). El estado cognitivo se evaluó mediante la versión en español del Mini-Mental Test. Los niveles de lipoproteínas se midieron con una prueba de perfil lipídico y la aptitud cardiorrespiratoria se valoró con la prueba de caminata de 6 minutos (Six-Minute Walking Test, 6MWT).
Resultados. El grupo con ejercicio mostró una mejora significativa (p<0,05) de la aptitud cardiorrespiratoria y de las concentraciones de colesterol HDL. Además, en la prueba de cognición se observó un efecto de gran tamaño en la orientación espacial, en la atención y en el cálculo. La reducción del colesterol LDL no fue significativa.
Conclusión. Un programa de entrenamiento progresivo y supervisado para mujeres mayores tratadas con lovastatina, podría mejorar la actividad cerebral relacionada con el colesterol HDL, lo cual podría retrasar el deterioro cognitivo.


Palabras clave


ejercicio; cognición; dislipidemias; inhibidores de hidroximetilglutaril-CoA reductasa; salud mental; envejecimiento

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Referencias


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